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Karimzadeh A, Yousefzadeh-Chabok S, Hemmati H, Andalib S. Gut-brain Axis Roles in Brain Tumors: Pathophysiological
Insights and Research Advances. Iran J Neurosurg 2024; 10 : 29
URL: http://irjns.org/article-1-454-en.html
URL: http://irjns.org/article-1-454-en.html
1- School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
2- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of General Surgery, Faculty of Medicine, Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran.
4- Research Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. AND Department of Neurology, Odense University Hospital, Odense, Denmark AND Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. ,sasan.andalib@health.sdu.dk
2- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of General Surgery, Faculty of Medicine, Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran.
4- Research Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. AND Department of Neurology, Odense University Hospital, Odense, Denmark AND Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (657 Views)
Background and Aim: This study reviewed the association between gut microbiota and primary brain malignancies, with a focus on underlying metabolic and immunologic mechanisms, and possible therapeutic approaches.
Methods and Materials/Patients: A literature search was carried out for a narrative review related to the microbial components of the gut-brain axis (GBA) and their potential effects on brain tumors’ formation, growth, and course of treatment with a focus on recent publications.
Results: Studies have highlighted likely mechanisms of the crosstalk between the gut and brain through an anatomical and physiological pathway, known as the GBA. Moreover, the metabolites and signaling molecules produced by gut microbiota were found to be involved in maintaining the blood-brain barrier (BBB) integrity and brain homeostasis. In addition, studies have revealed the potential negative effect of gut dysbiosis on tumorigenesis and deleterious inflammatory and immunological cascades within the brain. Pre-clinical and clinical investigations indicated the role of modulation of gut microbiome in brain tumors.
Conclusion: Previous investigations on interactions between gut microbiome and central nervous system (CNS) have revealed potential pathways through which interventions on microbiota can regulate brain tumor epigenetics and microenvironment. The findings on modifying microbiota utilizing probiotics, fecal microbial transplantation, and supplemented dietary regimen were promising; nonetheless, further investigation is needed to translate these findings into clinical brain cancer treatment applications.
Methods and Materials/Patients: A literature search was carried out for a narrative review related to the microbial components of the gut-brain axis (GBA) and their potential effects on brain tumors’ formation, growth, and course of treatment with a focus on recent publications.
Results: Studies have highlighted likely mechanisms of the crosstalk between the gut and brain through an anatomical and physiological pathway, known as the GBA. Moreover, the metabolites and signaling molecules produced by gut microbiota were found to be involved in maintaining the blood-brain barrier (BBB) integrity and brain homeostasis. In addition, studies have revealed the potential negative effect of gut dysbiosis on tumorigenesis and deleterious inflammatory and immunological cascades within the brain. Pre-clinical and clinical investigations indicated the role of modulation of gut microbiome in brain tumors.
Conclusion: Previous investigations on interactions between gut microbiome and central nervous system (CNS) have revealed potential pathways through which interventions on microbiota can regulate brain tumor epigenetics and microenvironment. The findings on modifying microbiota utilizing probiotics, fecal microbial transplantation, and supplemented dietary regimen were promising; nonetheless, further investigation is needed to translate these findings into clinical brain cancer treatment applications.
Article number: 29
Type of Study: Review |
Subject:
Brain Tumors
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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