en Gamma Knife Radiosurgery Case report <p style="text-align: justify;"><strong>Background and Importance:</strong> Hypoparathyroidism is due to parathyroid hormone deficiency and categorized as an endocrine&nbsp;disorder. Acute clinical presentations of hypoparathyroidism are muscle cramps and spasms, tetany, weakness, paresthesia and seizure.&nbsp;Hypoparathyroidism may be accompanied with psychosis, depressio n, seizures and extrapyramidal manifestations in chronic condit ion.<br> <strong>Case Presentation:</strong> The present case reported about a 37-year-old man who presented with the history of several episodes of seizures,&nbsp;slurred speech, progressive limbs and trunk stiffness and increa sed muscle tone and rigidity.<br> <strong>Conclusion:</strong> Paraclinical investigations revealed hypocalcemia and very low parathyroid hormone levels with extensive intracranial&nbsp;calcification involving bilateral basal ganglia, cerebellum and subcortical white matters on brain CT scan.</p> Hypoparathyroidism, Parathyroid Hormone, Intracranial Calcification 22 24 http://irjns.org/browse.php?a_code=A-10-65-6&slc_lang=en&sid=1 Mohamad Reza Ehsaei محمد رضا احصایی ehsaeemr@mums.ac.ir 10031947532846003181 10031947532846003181 Yes MD, Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohamad Ali Abouei Mehrizi محمد علی ابویی مهریزی 10031947532846003182 10031947532846003182 No MD, Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Farimah Firouz فریماه فیروز 10031947532846003183 10031947532846003183 No MD, Department of Neurology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran