en Gamma Knife Radiosurgery Case report <p style="text-align: justify;"><strong>Background and Importance: </strong>The coexistence of pituitary adenoma and another type of brain tumor is a very rare clinical scenario. Even though such a presentation can be an incidental event but the possible pathogenesis of coexistence of different lesions in the sella and suprasellar region has not yet been elucidated.</p> <p style="text-align: justify;"><strong>Case Presentation:</strong> Two cases of concomitant sellar and suprasellar region tumors are reported. A 37-year-old lady with Prolactinoma and a suprasellar meningioma and a 42-year-old Acromegalic man with suprasellar meningioma and a pituitary adenoma (PA).</p> <p style="text-align: justify;"><strong>Conclusion</strong>: Both meningiomas were removed transcranially while the Prolactinoma could be managed medically and the growth hormone (GH) secreting adenoma was removed trans-sphenoidally. The visual problems and hormonal imbalances of both patients improved postoperatively and there has been no sign of recurrence of the lesions after a mean of five years follow up. The literature is reviewed on this topic and the possible pathogenesis and management protocol of similar lesions are discussed.</p> Acromegaly, Multiple primary brain tumor, Prolactinoma, Suprasellar meningioma, Pituitary adenoma 43 46 http://irjns.org/browse.php?a_code=A-10-100-16&slc_lang=en&sid=1 Seyed-Abolghasem Mortazavi سیدابولقاسم مرتضوی Mortazavi@gmail.com 10031947532846002517 10031947532846002517 No Mohamad Shirani محمد شیرانی Shirani@gmail.com 10031947532846002518 10031947532846002518 No Saeed Saeedinia سعید سعیدی نیا Saeedinia@gmail.com 10031947532846002519 10031947532846002519 No Reza Sanjari رضا سنجری Sanjari@gmail.com 10031947532846002520 10031947532846002520 No Hamed Hanif حامد حنیف Hanif@gmail.com 10031947532846002521 10031947532846002521 No Abbas Amirjamshidi عباس امیرجمشیدی Amirjamshidi@gmail.com 10031947532846002522 10031947532846002522 Yes