en Gamma Knife Radiosurgery <p style="text-align: justify;">Apoptosis is a kind of programmed cell death that is naturally necessary for homeostasis and some processes like organogenesis and implantation&nbsp;of embryo; so it is not pathologic and harmful all the time. The purpose of this commentary was to describe the ways of stimulating and&nbsp;inhibiting the apoptosis process; because rather in the therapeutic protocols we should stimulate or inhibit the process in order to minimize the&nbsp;effects of the traumas and injuries. For using the first results in therapeutic protocols; for example, in order to take action against tumors, we&nbsp;should stimulate apoptosis with chemotherapeutic drugs or other alternatives. On the contrary, in physical traumas of spinal cord, we should&nbsp;inhibit apoptosis with chemical drugs or other alternatives in order to reduce secondary paralysis and other side effects. By collecting the present&nbsp;results and comparing them with our previous original articles, we reached some ideas for the future original research and therapeutic proposals.</p> Apoptosis, Spinal Cord, CNS, Pathology, Neuropathology 29 30 http://irjns.org/browse.php?a_code=A-10-176-1&slc_lang=en&sid=1 Hassan Ahmadvand حسن احمدوند 10031947532846003072 10031947532846003072 No Professor of Biochemistry, Lorestan University of Medical Sciences, Khorramabad, Iran Seyyed Amir Yasin Ahmadi سیدامیریاسین احمدی 10031947532846003073 10031947532846003073 No Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Ahmad Sayahi احمد سیاحی 10031947532846003074 10031947532846003074 No Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Jafar Rezaian جعفر رضاییان 10031947532846003075 10031947532846003075 Yes Assistant Professor of Neuroanatomy, Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran