en Gamma Knife Radiosurgery Case report <p style="text-align: justify;"><strong>Background & Importance:</strong> The use of local hemostatic agents in neurosurgery is mandatory in order to control the sequelae of intracerebal&nbsp;hemorrhage. It is widely used in oxidized regenerated cellulose (Surgicel&trade;).<br> <strong>Case Presentation:</strong> A 54-year-old man previously operated for grade II meningioma came back to our attention due to the onset of left&nbsp;side arm weakness one month after surgery. The CT scan and MRI showed an extensive lesion on the surgical site with the suspect of&nbsp;intracranial abscess. Intraoperative detections suggested the features of a granulomatous foreign body reaction.<br> <strong>Conclusion:</strong> The occurrence of granulomatous reaction to oxidized regenerated cellulose, when used as hemostatic agent, is a very rare&nbsp;finding following intracranial surgery.</p> Foreign Body Reaction, Surgicel™, Oxidized Regenerated Cellulose, Topical Haemostatic Agents, Intracranial Abscess, Brain Surgery 20 23 http://irjns.org/browse.php?a_code=A-10-38-1&slc_lang=en&sid=1 Matteo Capozza متئو کاپازو 10031947532846003120 10031947532846003120 Yes MD, Department of Neurosurgery, University of Florence, Italy Gastone Pansini گاستون پانسینی 10031947532846003121 10031947532846003121 No MD, Neurosurgical Unit, Careggi General Hospital, Florence, Italy Anna Maria Buccoliero آناماریا بوکولیه رو 10031947532846003122 10031947532846003122 No MD, Unit of Pathology, Meyer Hospital, Florence, Italy Giovanni Barbagli جیووانی بارباگلی 10031947532846003123 10031947532846003123 No MD, Department of Neurosurgery, University of Florence, Italy Bahman Ashraf-Noubari بهمن اشرف نوبری 10031947532846003124 10031947532846003124 No MD, Department of Neurosurgery, University of Florence, Italy Furio Mariotti فیوریو ماریوتی 10031947532846003125 10031947532846003125 No MD, Neurosurgical Unit, Careggi General Hospital, Florence, Italy Franco Ammannati فرانکو آماناتی 10031947532846003126 10031947532846003126 No MD, Neurosurgical Unit, Careggi General Hospital, Florence, Italy