en Skull Base Case report <div style="text-align: justify;"><strong>Background and Aim:</strong> Mortality associated with post-coronavirus disease 2019 (COVID-19) rhino-orbital cerebral mucormycosis (ROCM) is an evolving concern. Association of COVID-19, corticosteroid therapy, and uncontrolled diabetes mellitus (DM) are considered predisposing<br> factors for ROCM. We present two cases of successful treatment leading to patient survival for post-COVID-19, stage 4c-ROCM.<br> <strong>Case Presentation: </strong>Two middle-aged men with poorly controlled DM were referred to our hospital for post-COVID-19 ROCM. They had received intravenous antivirals and dexamethasone as treatment in a primary center. Both patients had unilateral oculofacial pain and swelling<br> followed by acute visual loss, unilateral proptosis, facial palsy, and trigeminal hypoesthesia. A computed tomography scan revealed opacity and bony erosion of paranasal sinuses (PNS). Obtained specimens confirmed mucormycosis agent on histopathological examination. After the failure of conservative treatments, retrobulbar injections of liposomal-amphotericin B, PNS debridement, and orbital exenteration, both patients developed blurred consciousness owing to the extension of the infection into the intracranial cavity. Brain magnetic resonance imaging revealed a right frontal lobe abscess in case 1 and a left frontal sinus abscess and involvement in case 2. Both underwent transcranial debridement and resection of necrotic tissue and drainage of the abscess. At follow-up, the patients were in good condition, and the fungal cultures were negative for mucormycosis agents.<br> <strong>Conclusion:</strong> ROCM may be a complication of COVID-19 in high-risk patients. Control of the patient&rsquo;s underlying systemic condition and prompt treatment with antifungal agents, along with timely aggressive resection of cerebral abscess and necrotic paranasal tissues, are the mainstays<br> of management for ROCM.</div> Mucormycosis, COVID -19, Cerebral, Diabetes mellitus, Corticotherapy 0 0 http://irjns.org/browse.php?a_code=A-10-134-1&slc_lang=en&sid=1 Hooshang Saberi hgsaberi@yahoo.com 10031947532846009257 10031947532846009257 Yes Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Nazi Derakhshanrad nderakhshan@hotmail.com 10031947532846009258 10031947532846009258 No Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Pedram Sedaghat pedram.sedaghat@yahoo.com 10031947532846009259 10031947532846009259 No Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Ehsan Jaberansary ehsanjaberansary@yahoo.com 10031947532846009260 10031947532846009260 No Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Asghar Hajipour asghar46haji@gmail.com 10031947532846009261 10031947532846009261 No Department of Anesthesiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Pouyan Aminishakib aminishakib@tums.ac.ir 10031947532846009262 10031947532846009262 No Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran