en Spine Case report <div style="text-align: justify;"><strong>Background and Importance: </strong>Plasmacytoma is more likely to involve the spine with up to 50%, most commonly in the thoracic spine.<br> <strong>Case Presentation: </strong>This study examined a patient with solitary plasmacytoma with neck pain and abnormal C1-C2 range of motion, which happened to have an osteolytic C2 lesion on CT scanning.&nbsp;The patient underwent a fluoroscopically guided anterior percutaneous C2 vertebroplasty without posterior fusion, leading to management of pain, maintenance of normal motions, and restoration of cervical alignment.<br> <strong>Conclusion: </strong>This case represents fluoroscopically guided anterior percutaneous C2 vertebroplasty as an effective treatment for C2 osteolytic lesions with an abnormal range of motion, which can be&nbsp;considered in selected cases as an alternative approach for demanding open surgical approaches to this challenging region.</div> Vertebroplasty, Solitary plasmacytoma, Pain 35 40 http://irjns.org/browse.php?a_code=A-10-185-2&slc_lang=en&sid=1 Majid Reza Farrokhi farrokhimr@yahoo.com 10031947532846005066 10031947532846005066 Yes Professor of Neurosurgery, Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran And Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran Amir Tarokh amirtarokh79@yahoo.com 10031947532846005067 10031947532846005067 No Neurosurgeon, Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran And Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran Javad Safaei javad.safaee@gmail.com 10031947532846005068 10031947532846005068 No Neurosurgeon, Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran And Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran