en Research <div style="text-align: justify;"><strong>Background and Aim: </strong>The assessment of Quality of Life (QoL) as a measurement of Traumatic&nbsp;Brain Injury (TBI) outcome can play a key role in identifying the adverse effects of TBI. There is no&nbsp;study on the evaluation of psychometric properties of the Persian version of Short Form Health<br> Survey Questionnaire (SF-36) in the TBI patient population. Therefore, the present study aimed to&nbsp;validate and test the reliability of the Persian version of the SF-36 in patients with TBI.<br> <strong>Methods and Materials/Patients: </strong>In the present cross-sectional study, 185 patients with TBI were&nbsp;selected by non-probability and consecutive sampling. First, the construct validity of the Persian&nbsp;version of the SF-36 questionnaire was evaluated using the Confirmatory Factor Analysis (CFA) in<br> AMOS-22, and then the internal consistency reliability and item-total score correlation of each&nbsp;subscale were assessed by SPSS V. 22.<br> <strong>Results: </strong>Results of CFA indicated that the dimensionality of SF-29 questionnaire with eight-factor&nbsp;structure among the Iranian TBI patients had construct validity (GFI=0.825, CFI=0.963, NFI=0.919,&nbsp;TLI=0.957, RMSEA=0.06) by eliminating 6 items and freeing some of the covariance errors&nbsp;between items, but the two-factor dimensionality (physical and psychological components of&nbsp;QoL) of this questionnaire was not approved. Internal consistency of the eight-factor form of SF-29 subscales was acceptable to excellent (=&alpha;0.70 to 0.99). Correlation analysis of item-total score&nbsp;for determining the construct validity of SF-29 indicated that except for 2 items, all items of the&nbsp;questionnaire had a positive and strong correlation with their subscales (r=0.40 to 0.99, P<0.0001).<br> <strong>Conclusion:</strong> Persian version of SF-29 with an eight-factor construct had good validity and reliability&nbsp;and could be used to measure health-related QoL in Iranian patients with TBI.</div> Brain injuries, Traumatic, Quality of Life, Surveys and questionnaires, Measurement, Reliability, Validityeliability 79 91 http://irjns.org/browse.php?a_code=A-10-283-1&slc_lang=en&sid=1 Sajjad Rezaei 10031947532846004200 10031947532846004200 No Department of Psychology, University of Guilan, Rasht, Iran Zahra Khaksari zahra.khaksari@pnu.ac.ir (Corresponding author) 10031947532846004201 10031947532846004201 Yes Department of Psychology, Payame Noor University,Tehran, Iran