en Spine Clinical Trial <div style="text-align: justify;"><strong>Background and Aim:</strong> Bleeding during surgery is one of the most common surgical complications.&nbsp;In this study, we decided to determine the effect of Tranexamic Acid (TA) in reducing blood loss in&nbsp;patients undergoing spinal surgeries.<br> <strong>Methods and Materials/Patients:</strong> In this clinical trial, 100 patients undergoing spinal surgeries&nbsp;were randomly divided into two groups. One group received TA and the other was selected as the&nbsp;control group. Patients in the treatment group received 1 gram of intravenous TA and another 250&nbsp;milligram intravenously, one hour after the beginning of the surgery. Bleeding during the surgery,&nbsp;in the first 24 hours and the first 48 hours were recorded separately. The need for transfusion and&nbsp;its volume, as well as the hospital stay length were compared in the two groups.&nbsp;<br> <strong>Results: </strong>Bleeding during surgery in TA group was significantly lower than that in the control group&nbsp;(433 ml vs. 522 ml respectively, P=0.009). Also, during the first 24 hours after surgery, bleeding in<br> TA group was significantly less than that in the control group (P=0.011). During the second 24 hours&nbsp;after surgery, bleeding was similar between the two groups (P=0.112). The values of hemoglobin&nbsp;in both groups slowly decreased and the trend of decrease was not significantly different between&nbsp;them (P=0.154).<br> <strong>Conclusion:</strong> In spinal surgeries, TA administration in the beginning of the process reduces&nbsp;surgical bleeding during surgery and in the first 24 hours after surgery. Considering the possible&nbsp;complications, TA administration is suggested for patients with hemoglobin less than 12 g/dl.&nbsp;Future studies are needed to conclude the advantages and disadvantages of TA administration in&nbsp;spinal surgeries.</div> Tranexamic acid, Spinal surgery, Surgical bleeding, Blood transfusion 71 78 http://irjns.org/browse.php?a_code=A-10-217-1&slc_lang=en&sid=1 Majid Rezvani m.rezvani53@gmail.com 10031947532846004193 10031947532846004193 No Medical School of Isfahan University of Medical Sciences, Isfahan, Iran Homayoun Tabesh homtabesh@yahoo.com 10031947532846004194 10031947532846004194 No Medical School of Isfahan University of Medical Sciences, Isfahan, Iran Meisam Adimi meisammeisami04@gmail.com 10031947532846004195 10031947532846004195 Yes Medical School of Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Alavi mohammadalavi1361@gmail.com 10031947532846004196 10031947532846004196 No Medical School of Isfahan University of Medical Sciences, Isfahan, Iran Abolfazl Zareian dr.z.abolfazl77@gmail.com 10031947532846004197 10031947532846004197 No Medical School of Isfahan University of Medical Sciences, Isfahan, Iran Mitra Rahiminejad mitra.rahiminejad@gmail.com 10031947532846004198 10031947532846004198 No Medical School of Isfahan University of Medical Sciences, Isfahan, Iran Mehrdad Lari mehrdad.lary@gmail.com 10031947532846004199 10031947532846004199 No Medical School of Isfahan University of Medical Sciences, Isfahan, Iran