en Skull Base Case report <div style="text-align: justify;"><strong>Background and Importance:</strong> Symptomatic Rathke&rsquo;s cleft cyst is a rare lesion that often presents without any symptoms.&nbsp;<br> Case Presentation: We report a 40-year-old female with symptomatic Rathke&rsquo;s cleft cyst located in the sellar and suprasellar region. She presented with visual disturbance, headache, weight gain, hypothyroidism and amenorrhea. The patient underwent surgery and the pathological examination confirmed Rathke&rsquo;s cleft cyst.<br> <strong>Conclusion:</strong> Although the symptomatic Rathke&rsquo;s cleft cyst is rare, the differential diagnosis must be done with intrasellar and suprasellar lesions.</div> Rathke’s cleft cyst, Suprasellar lesions, Decreased visual acuit 41 44 http://irjns.org/browse.php?a_code=A-10-189-4&slc_lang=en&sid=1 Mohammad Samadian Mdsamadian@gmail.com 10031947532846002044 10031947532846002044 No Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Kaveh Ebrahim Zadeh dr.kavehebrahimzadeh@gmail.com 10031947532846002045 10031947532846002045 No Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. karim Moradian Kokhdan srazme82@gmail.com 10031947532846002046 10031947532846002046 Yes Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Saeed Razmeh srazmeh@yahoo.com 10031947532846002047 10031947532846002047 No Department of Neurology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. Guive Sharifi guivesharifi@gmail.com 10031947532846002048 10031947532846002048 No Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Omidvar Rezaee jomenarenji@gmail.com 10031947532846002049 10031947532846002049 No Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Elena Jamali elena.jamali@gmail.com 10031947532846002050 10031947532846002050 No Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shahram Sabeti 10031947532846002051 10031947532846002051 No Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.