en Vascular Neurosurgery Research <p><strong>Background and Aim:</strong> Post-operative loss of vision is not a common but dramatic complication. This is most often reported after spinal and cardiac surgeries. Ischemic optic neuropathy is the primary cause, but its etiology remains unclear. Retinal blood perfusion depends on mean arterial pressure and intraocular pressure (IOP). In spinal surgery, both of these can be altered by the type of prone-position surgery. Because different anesthetic agents can be used for anesthesia in spine surgery, we conducted this randomized clinical trial to compare the effects of propofol and isoflurane as maintenance anesthesia on IOP during spinal surgery in the prone position.</p> <p><strong>Methods and Materials/Patients:</strong> IOP was measured with the Tonopen Richert device in five steps before and after induction of anesthesia and during surgery every 30 minutes. A total of 72 patients were enrolled in this study.</p> <p><strong>Results:</strong> IOP decreased after induction of anesthesia with propofol, but significantly increased in patients receiving isoflurane as maintenance of anesthesia in a prone position compared with the propofol group. Systolic and diastolic blood pressure and duration of surgery in a prone position were also associated with increased IOP.</p> <p><strong>Conclusion:</strong> The present study showed that the group under anesthesia with propofol had significantly lower IOP than the group anesthetized with isoflurane.</p> Intraocular pressure (IOP), Isoflurane, Propofol, Prone position 0 0 http://irjns.org/browse.php?a_code=A-10-703-3&slc_lang=en&sid=1 Hassan Behboudi 100319475328460013187 100319475328460013187 No Department of Ophthalmology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Mohammad Javad Mohammdi 100319475328460013188 100319475328460013188 No Department of Ophthalmology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Ali Mohammadzadeh Jouryabi 100319475328460013189 100319475328460013189 No Department of Anesthesiology, Anesthesiology Research Center, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran. Shahrokh Yousefzadeh-Chabok 100319475328460013190 100319475328460013190 No Road Trauma Research Center, School of Medicine, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. Mohammadreza Panjtan Panah 100319475328460013191 100319475328460013191 No Department of Ophthalmology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Babak Alijani drbabakalij@gums.ac.ir 100319475328460013192 100319475328460013192 No Department of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Mohammad Haghighi 100319475328460013193 100319475328460013193 No Department of Medical Surgical Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran. Maryam Khoshbakht-Pishkhani 100319475328460013195 100319475328460013195 No Department of Medical Surgical Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran. Ehsan Kazemnezhad Leyli 100319475328460013196 100319475328460013196 No Department of Biostatistics, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran. Ali Ashraf crd_poursina@gums.ac.ir 100319475328460013194 100319475328460013194 Yes Clinical Research Development Unit, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.